https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30416 Wed 11 Apr 2018 17:10:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29666 10 mg/L, or who were taking anti-inflammatory medications or n-3PUFA supplements, 126 participants (age 77.6 ± 7.3 years; females, 46%) were included in the analysis. After multivariate adjustments, O3I was inversely associated with CRP (β = −0.209, p < 0.05) and monocyte cell counts (β = −0.205, p < 0.05), and total n-3PUFA was inversely related to WBC (β = −0.238, p < 0.05), neutrophils (β = −0.212, p < 0.05) and monocytes (β = −0.246, p < 0.05). However no association between fibrinogen and O3I or total n-3PUFA was detected. Conclusions: This study demonstrated a negative association between O3I and biomarkers of inflammation in an older population. The findings support a potential role for n-3PUFA supplementation in the management of inflammatory diseases.]]> Wed 11 Apr 2018 16:52:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29661 Wed 11 Apr 2018 16:03:15 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26544 Wed 11 Apr 2018 15:40:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30774 Wed 11 Apr 2018 11:53:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29551 p=0.06), WC (r = −0.118, p < 0.01) and waist-to-hip ratio (WHR; r = −0.149, p < 0.001). Stratification of data by sex (females, n = 349; males, n = 271) indicated that these associations were sex-specific. Females displayed an inverse association between the omega-3 index and BMI (r = −0.146, p < 0.01) and WC (r = −0.125, p < 0.05). In contrast, no significant association between the omega-3 index and anthropometric measures was detected in males. After correcting for the potentially confounding effects of age, household income, fish oil supplement status, daily dietary energy intake and total physical activity times, the omega-3 index was inversely associated with BMI and WC in females but not males. Conclusions: Omega-3 status was associated with weight status, particularly in older women but not in men. These results suggest the need for sex-based intervention trials to examine the role of dietary intake and/or supplementation of LCn-3PUFA in weight management of older adults.]]> Wed 09 Mar 2022 16:02:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24609 trend=0·015). A similar but non-significant trend was seen in overweight men. After adjusting for BMI, no associations were found between n-3I and fasting blood glucose, HbA1c, insulin or HOMA-IR. In conclusion, higher erythrocyte n-3 PUFA status may be protective against the development of T2D in overweight women. Further research is warranted to determine whether dietary interventions that improve n-3 PUFA status can improve measures of IR, and to further elucidate sex-dependent differences.]]> Wed 09 Mar 2022 15:58:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24083 Thu 04 Nov 2021 10:38:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31374 Sat 24 Mar 2018 08:43:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29660 CYP2R1, CYP27B1 and CYP24A1) and the Vitamin D receptor gene (VDR). This analysis was conducted in the context of dietary Vitamin D, and background methyl donor related biochemistry, with adjustment for several dietary and lifestyle variables. Percentage methylation at CpG sites was assessed in peripheral blood cells using methylation sensitive and dependent enzymes and qPCR. Standard analytical techniques were used to determine plasma 25(OH)D and homocysteine, and serum folate and B12, with the relationship to methylation status assessed using multi-variable regression analysis. CYP2R1 and VDR methylation were found to be independent predictors of plasma 25(OH)D, when adjusted for Vitamin D intake and other lifestyle variables. CYP24A1 was related to plasma 25(OH)D directly, but not in the context of Vitamin D intake. Methyl-group donor biochemistry was associated with the methylation status of some genes, but did not alter the relationship between methylation and plasma 25(OH)D. Modulation of methylation status of CYP2R1, CYP24A1 and VDR in response to plasma 25(OH)D may be part of feedback loops involved in maintaining Vitamin D homeostasis, and may explain a portion of the variance in plasma 25(OH)D levels in response to intake and sun exposure. Methyl-group donor biochemistry, while a potential independent modulator, did not alter this effect.]]> Mon 26 Apr 2021 10:02:52 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32771 Mon 23 Jul 2018 15:44:21 AEST ]]>